In tangential flow filtration (TFF), the liquid flows parallel to the membrane surface, unlike traditional dead-end filtration where it flows perpendicularly. A portion passes through the membrane as permeate, while larger particles or molecules are retained in the main tangential flow and continuously swept along the membrane. This cross-flow minimizes fouling and cake formation, ensuring stable filtration performance over time – ideal for concentration, diafiltration, or protein purification.
Tangential Flow Filtration Equipment
Tangential Flow Filtration (TFF) plays a pivotal role in modern bioprocessing, enabling gentle and efficient protein purification, concentration, and diafiltration. Our TFF equipment supports biopharmaceutical products from development through production, offering GMP-compliant, flexible solutions that integrate seamlessly into existing process systems.
- GMP- and FDA-Compliant Portfolio: Our TFF filters and components are designed specifically for biopharmaceutical applications, fully cGMP and GMP-compliant, and suitable for both single-use and multi-use processes – delivering maximum quality, safety, and reliability.
- Precise Sensor Technology for Process Control: High-performance pumps and integrable sensors ensure precise flow rates, controlled pressure, and stable temperatures, allowing your processes to be accurately monitored and reliably reproducible.
- Seamless Integration into Existing Systems: Our filter capsules and modules connect effortlessly via standardized fittings to bioreactors, purification skids, and TFF systems – enabling flexible, fast, and secure process integration.
Frequently asked questions about Tangential Flow Filtration:
What is the principle of tangential flow filtration?2026-04-13T13:05:23+00:00
What are the advantages of TFF over conventional filtration?2026-04-13T13:04:16+00:00
Tangential flow filtration (TFF) offers clear benefits:
- Higher yield: Products remain in solution, reducing losses.
- Reduced fouling: Continuous cross-flow prevents membrane blockage.
- Gentle on sensitive molecules: Proteins and other biomolecules are handled delicately.
- Consistent performance: Stable filtration over extended runs.
- Easy scaling: Processes can be smoothly transferred from lab to pilot and production scale.
How can TFF solutions be integrated into existing process systems?2026-04-13T13:01:16+00:00
TFF modules and preconfigured assemblies feature standardized connections, allowing seamless integration into bioreactors, purification skids, or TFF systems. Installation and component replacement are quick, safe, and require minimal adjustments, enabling flexible and efficient process integration.
Which sensors are suitable for tangential filtration?2026-04-13T13:08:20+00:00
Tangential filtration or TFF systems require highest precision in terms of flow rate measurement. The most suiting sensors are the ones using the Coriolis effect. On request, we’ll gladly offer you our multi-use or single-use versions of the Coriolis sensors.